Tom Holland: Peter Parker, Spider-Man

Samuel L. Jackson: Nick Fury

Jake Gyllenhaal: Quentin Beck, Mysterio

Marisa Tomei: May Parker

Jon Favreau: Happy Hogan

Zendaya: MJ

Jacob Batalon: Ned Leeds

Tony Revolori: Flash Thompson

Angourie Rice: Betty Brant

Remy Hii: Brad Davis

Martin Starr: Mr. Harrington

J.B. Smoove: Mr. Dell

Jorge Lendeborg Jr.: Ionello

Cobie Smulders: Maria Hill

Numan Acar: Dimitri

Zach Barack: Zach