Xolo Maridueña: Jaime Reyes
Bruna Marquezine: Jenny Kord
Becky G: Khaji-Da (voice)
Damián Alcázar: Alberto Reyes
George Lopez: Rudy Reyes
Adriana Barraza: Nana Reyes
Belissa Escobedo: Milagro Reyes
Elpidia Carrillo: Rocio Reyes
Susan Sarandon: Victoria Kord
Harvey Guillén: Dr. Sanchez
Raoul Max Trujillo: Carapax
Jorge Jimenez: Tío Chema
Eyra Aguero Joubert: Tía Maru (as Eyra Agüero Joubert)
Gabriella Ortiz: Tía Letty
Vicente Ydrach: Old Man in Airport